Lab Publications

Kang HM, Lee JH. Spatial Single-Cell Technologies for Exploring Gastrointestinal Tissue Transcriptome. Compr Physiol. 2023 Jun 26;13(3):4709-4718. doi: 10.1002/cphy.c210053. PubMed PMID: 37358516; PubMed Central PMCID: PMC10386894.

Xi J, Park SR, Lee JH, Kang HM. SiftCell: A robust framework to detect and isolate cell-containing droplets from single-cell RNA sequence reads. Cell Syst. 2023 Jul 19;14(7):620-628.e3. doi: 10.1016/j.cels.2023.06.002. PubMed PMID: 37473732; NIHMSID:NIHMS1919287.

Cobb T, Hwang I, Soukar M, Namkoong S, Cho US, Safdar M, Kim M, Wessells RJ, Lee JH. Iditarod, a Drosophila homolog of the Irisin precursor FNDC5, is critical for exercise performance and cardiac autophagy. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2220556120. doi: 10.1073/pnas.2220556120. Epub 2023 Sep 18. PubMed PMID: 37722048. 

Hwang I, Kim M. Muscular Sestrins: Roles in Exercise Physiology and Stress Resistance. Biomolecules. 2023 Apr 23;13(5):722. doi: 10.3390/biom13050722. PMID: 37238592; PMCID: PMC10216764.

Solanki S, Sanchez K, Ponnusamy V, Kota V, Bell HN, Cho CS, Kowalsky AH, Green M, Lee JH, Shah YM. Dysregulated Amino Acid Sensing Drives Colorectal Cancer Growth and Metabolic Reprogramming Leading to Chemoresistance. Gastroenterology. 2023 Mar;164(3):376-391.e13. doi: 10.1053/j.gastro.2022.11.014. Epub 2022 Nov 18. PubMed PMID: 36410445; NIHMSID:NIHMS1917205.

Ma F, Plazyo O, Billi AC, Tsoi LC, Xing X, Wasikowski R, Gharaee-Kermani M, Hile G, Jiang Y, Harms PW, Xing E, Kirma J, Xi J, Hsu JE, Sarkar MK, Chung Y, Di Domizio J, Gilliet M, Ward NL, Maverakis E, Klechevsky E, Voorhees JJ, Elder JT, Lee JH, Kahlenberg JM, Pellegrini M, Modlin RL, Gudjonsson JE. Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis. Nat Commun. 2023 Jun 12;14(1):3455. doi: 10.1038/s41467-023-39020-4. PubMed PMID: 37308489; PubMed Central PMCID: PMC10261041.

Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 Jun 6;35(6):1009-1021.e9. doi: 10.1016/j.cmet.2023.03.021. Epub 2023 Apr 20. PubMed PMID: 37084733.

Gurkar AU, Gerencser AA, Mora AL, Nelson AC, Zhang AR, Lagnado AB, Enninful A, Benz C, Furman D, Beaulieu D, Jurk D, Thompson EL, Wu F, Rodriguez F, Barthel G, Chen H, Phatnani H, Heckenbach I, Chuang JH, Horrell J, Petrescu J, Alder JK, Lee JH, Niedernhofer LJ, Kumar M, Königshoff M, Bueno M, Sokka M, Scheibye-Knudsen M, Neretti N, Eickelberg O, Adams PD, Hu Q, Zhu Q, Porritt RA, Dong R, Peters S, Victorelli S, Pengo T, Khaliullin T, Suryadevara V, Fu X, Bar-Joseph Z, Ji Z, Passos JF. Spatial mapping of cellular senescence: emerging challenges and opportunities. Nat Aging. 2023 Jul;3(7):776-790. doi: 10.1038/s43587-023-00446-6. Epub 2023 Jul 3. Review. PubMed PMID: 37400722. 

Cho CS, Kim Y, Park SR, Kim B, Davis C, Hwang I, Brooks SV, Lee JH, Kim M. Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1/p62 accumulation. Autophagy. 2022 Oct;18(10):2303-2322. doi: 10.1080/15548627.2021.2016255. Epub 2021 Dec 29. PubMed PMID: 34964695; PubMed Central PMCID: PMC9542799.

Wessells RJ, Lee JH. Sestrin/FNDC5: An ancient axis connecting exercise and thermoregulation. Acta Physiol (Oxf). 2022 Apr;234(4):e13804. doi: 10.1111/apha.13804. Epub 2022 Feb 23. PubMed PMID: 35184392.

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. Nat Aging. 2022 Dec;2(12):1090-1100. doi: 10.1038/s43587-022-00326-5. Epub 2022 Dec 20. PubMed PMID: 36936385; PubMed Central PMCID: PMC10019484.

Liu Q, Lee JH, Kang HM, Kim CH. Identification of the niche and mobilization mechanism for tissue-protective multipotential bone marrow ILC progenitors. Sci Adv. 2022 Nov 25;8(47):eabq1551. doi: 10.1126/sciadv.abq1551. Epub 2022 Nov 23. PubMed PMID: 36417511; PubMed Central PMCID: PMC9683709.

Xi J, Lee JH, Kang HM, Jun G. STtools: A Comprehensive Software Pipeline for Ultra-high Resolution Spatial Transcriptomics Data. Bioinform Adv. 2022;2(1). doi: 10.1093/bioadv/vbac061. Epub 2022 Sep 1. PubMed PMID: 36284674; PubMed Central PMCID: PMC9590442.

Do TH, Ma F, Andrade PR, Teles R, de Andrade Silva BJ, Hu C, Espinoza A, Hsu JE, Cho CS, Kim M, Xi J, Xing X, Plazyo O, Tsoi LC, Cheng C, Kim J, Bryson BD, O'Neill AM, Colonna M, Gudjonsson JE, Klechevsky E, Lee JH, Gallo RL, Bloom BR, Pellegrini M, Modlin RL. TREM2 macrophages induced by human lipids drive inflammation in acne lesions. Sci Immunol. 2022 Jul 22;7(73):eabo2787. doi: 10.1126/sciimmunol.abo2787. Epub 2022 Jul 22. PubMed PMID: 35867799; PubMed Central PMCID: PMC9400695.

Cho CS, Xi J, Si Y, Park SR, Hsu JE, Kim M, Jun G, Kang HM, Lee JH. Microscopic examination of spatial transcriptome using Seq-Scope. Cell. 2021 Jun 24;184(13):3559-3572.e22. doi: 10.1016/j.cell.2021.05.010. Epub 2021 Jun 10. PubMed PMID: 34115981; PubMed Central PMCID: PMC8238917. 

Kim M, Kowalsky AH, Lee JH. Sestrins in Physiological Stress Responses. Annu Rev Physiol. 2021 Feb 10;83:381-403. doi: 10.1146/annurev-physiol-031620-092317. Epub 2020 Oct 28. PubMed PMID: 33113341; PubMed Central PMCID: PMC7878365.

Park SR, Cho CS, Xi J, Kang HM, Lee JH. Holistic characterization of single-hepatocyte transcriptome responses to high-fat diet. Am J Physiol Endocrinol Metab. 2021 Feb 1;320(2):E244-E258. doi: 10.1152/ajpendo.00391.2020. PubMed PMID: 33103450; PubMed Central PMCID: PMC8260362.ct

Yang BA, Castor-Macias J, Fraczek P, Cornett A, Brown LA, Kim M, Brooks SV, Lombaert IMA, Lee JH, Aguilar CA. Sestrins regulate muscle stem cell metabolic homeostasis. Stem Cell Reports. 2021 Jul 29;. doi: 10.1016/j.stemcr.2021.07.014. [Epub ahead of print] PubMed PMID: 34388363. 

Klionsky DJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PubMed PMID: 33634751; PubMed Central PMCID: PMC7996087. 

Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH. Sestrins are evolutionarily conserved mediators of exercise benefits. Nat Commun. 2020 Jan 13;11(1):190. doi: 10.1038/s41467-019-13442-5. PubMed PMID: 31929512; PubMed Central PMCID: PMC6955242.

Park SR, Namkoong S, Friesen L, Cho CS, Zhang ZZ, Chen YC, Yoon E, Kim CH, Kwak H, Kang HM, Lee JH. Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage. Cell Rep. 2020 Aug 25;32(8):108077. doi: 10.1016/j.celrep.2020.108077. PubMed PMID: 32846134; PubMed Central PMCID: PMC7486130.

Kowalsky AH, Namkoong S, Mettetal E, Park HW, Kazyken D, Fingar DC, Lee JH. The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation. J Biol Chem. 2020 Feb 14;295(7):1769-1780. doi: 10.1074/jbc.RA119.010857. Epub 2020 Jan 8. PubMed PMID: 31915252; PubMed Central PMCID: PMC7029113.

Cho CS, Kowalsky AH, Lee JH. Pathological Consequences of Hepatic mTORC1 Dysregulation. Genes (Basel). 2020 Aug 5;11(8). doi: 10.3390/genes11080896. Review. PubMed PMID: 32764389; PubMed Central PMCID: PMC7465966.

Pereira BI, De Maeyer RPH, Covre LP, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers ES, Gomes DCO, Riddell NE, Maini MK, Teixeira VH, Janes SM, Gilroy DW, Larbi A, Mabbott NA, Ucar D, Kuchel GA, Henson SM, Strid J, Lee JH, Banchereau J, Akbar AN. Sestrins induce natural killer function in senescent-like CD8+ T cells. Nat Immunol. 2020 Jun;21(6):684-694. doi: 10.1038/s41590-020-0643-3. Epub 2020 Mar 30. PubMed PMID: 32231301; NIHMSID:NIHMS1598079.

Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardí M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M, Lee JH, Muñoz-Cánoves P. Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nat Commun. 2020 Jan 13;11(1):189. doi: 10.1038/s41467-019-13832-9. PubMed PMID: 31929511; PubMed Central PMCID: PMC6955241.

Cho CS, Kowalsky AH, Namkoong S, Park SR, Wu S, Kim B, James A, Gu B, Semple IA, Tohamy MA, Solanki S, Cho US, Greenson JK, Shah YM, Kim M, Lee JH. Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury. Cell Discov. 2019;5:60. doi: 10.1038/s41421-019-0131-9. eCollection 2019. PubMed PMID: 31754457; PubMed Central PMCID: PMC6868011.

Li R, Huang Y, Semple I, Kim M, Zhang Z, Lee JH. Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity. Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(1):H39-H48. doi: 10.1152/ajpheart.00008.2019. Epub 2019 Apr 26. PubMed PMID: 31026186; PubMed Central PMCID: PMC6692737.

Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, Patil DP, Kwak H, Lee JH, Jaffrey SR. m6A enhances the phase separation potential of mRNA. Nature. 2019 Jul;571(7765):424-428. doi: 10.1038/s41586-019-1374-1. Epub 2019 Jul 10. PubMed PMID: 31292544; PubMed Central PMCID: PMC6662915.

Ding B, Haidurov A, Chawla A, Parmigiani A, van de Kamp G, Dalina A, Yuan F, Lee JH, Chumakov PM, Grossman SR, Budanov AV. p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis. Oncotarget. 2019 Dec 10;10(65):6997-7009. doi: 10.18632/oncotarget.27367. eCollection 2019 Dec 10. PubMed PMID: 31857853; PubMed Central PMCID: PMC6916756.

Liu X, Yao Z, Jin M, Namkoong S, Yin Z, Lee JH, Klionsky DJ. Dhh1 promotes autophagy-related protein translation during nitrogen starvation. PLoS Biol. 2019 Apr;17(4):e3000219. doi: 10.1371/journal.pbio.3000219. eCollection 2019 Apr. PubMed PMID: 30973873; PubMed Central PMCID: PMC6459490.

Namkoong S, Ho A, Woo YM, Kwak H, Lee JH. Systematic Characterization of Stress-Induced RNA Granulation. Mol Cell. 2018 Apr 5;70(1):175-187.e8. doi: 10.1016/j.molcel.2018.02.025. Epub 2018 Mar 22. PubMed PMID: 29576526; PubMed Central PMCID: PMC6359928.

Cho CS, Park HW, Ho A, Semple IA, Kim B, Jang I, Park H, Reilly S, Saltiel AR, Lee JH. Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation. Hepatology. 2018 Oct;68(4):1331-1346. doi: 10.1002/hep.29742. Epub 2018 May 21. PubMed PMID: 29251796; PubMed Central PMCID: PMC6005718.

Namkoong S, Cho CS, Semple I, Lee JH. Autophagy Dysregulation and Obesity-Associated Pathologies. Mol Cells. 2018 Jan 31;41(1):3-10. doi: 10.14348/molcells.2018.2213. Epub 2018 Jan 23. Review. PubMed PMID: 29370691; PubMed Central PMCID: PMC5792710.

Woo YM, Kwak Y, Namkoong S, Kristjánsdóttir K, Lee SH, Lee JH, Kwak H. TED-Seq Identifies the Dynamics of Poly(A) Length during ER Stress. Cell Rep. 2018 Sep 25;24(13):3630-3641.e7. doi: 10.1016/j.celrep.2018.08.084. PubMed PMID: 30257221.

Cho CS, Lombard DB, Lee JH. SIRT3 as a regulator of hepatic autophagy. Hepatology. 2017 Sep;66(3):700-702. doi: 10.1002/hep.29271. Epub 2017 Jul 20. PubMed PMID: 28520180; PubMed Central PMCID: PMC5570665.

Kim M, Ho A, Lee JH. Autophagy and Human Neurodegenerative Diseases-A Fly's Perspective. Int J Mol Sci. 2017 Jul 23;18(7). doi: 10.3390/ijms18071596. Review. PubMed PMID: 28737703; PubMed Central PMCID: PMC5536083.

Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN. A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Nat Immunol. 2017 Mar;18(3):354-363. doi: 10.1038/ni.3665. Epub 2017 Jan 23. PubMed PMID: 28114291; PubMed Central PMCID: PMC5321575.

Ho A, Cho CS, Namkoong S, Cho US, Lee JH. Biochemical Basis of Sestrin Physiological Activities. Trends Biochem Sci. 2016 Jul;41(7):621-632. doi: 10.1016/j.tibs.2016.04.005. Epub 2016 May 10. Review. PubMed PMID: 27174209; PubMed Central PMCID: PMC4930368.

Kim M, Sandford E, Gatica D, Qiu Y, Liu X, Zheng Y, Schulman BA, Xu J, Semple I, Ro SH, Kim B, Mavioglu RN, Tolun A, Jipa A, Takats S, Karpati M, Li JZ, Yapici Z, Juhasz G, Lee JH, Klionsky DJ, Burmeister M. Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay. Elife. 2016 Jan 26;5. doi: 10.7554/eLife.12245. PubMed PMID: 26812546; PubMed Central PMCID: PMC4786408.

Ro SH, Xue X, Ramakrishnan SK, Cho CS, Namkoong S, Jang I, Semple IA, Ho A, Park HW, Shah YM, Lee JH. Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis. Elife. 2016 Feb 25;5:e12204. doi: 10.7554/eLife.12204. PubMed PMID: 26913956; PubMed Central PMCID: PMC4805551.

Lee JH, Cho US, Karin M. Sestrin regulation of TORC1: Is Sestrin a leucine sensor?. Sci Signal. 2016 Jun 7;9(431):re5. doi: 10.1126/scisignal.aaf2885. Review. PubMed PMID: 27273098; PubMed Central PMCID: PMC4902175.

Burmeister M, Lee JH, Schulman BA, Yapici Z, Tolun A, Juhasz G, Li JZ, Klionsky DJ. A role of autophagy in spinocerebellar ataxia-Rare exception or general principle?. Autophagy. 2016 Jul 2;12(7):1208-9. doi: 10.1080/15548627.2016.1170266. Epub 2016 Apr 22. PubMed PMID: 27105143; PubMed Central PMCID: PMC4990986.

Klionsky DJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. PubMed PMID: 26799652; PubMed Central PMCID: PMC4835977. 

Kim H, An S, Ro SH, Teixeira F, Park GJ, Kim C, Cho CS, Kim JS, Jakob U, Lee JH, Cho US. Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Nat Commun. 2015 Nov 27;6:10025. doi: 10.1038/ncomms10025. PubMed PMID: 26612684; PubMed Central PMCID: PMC4674687.

Ro SH, Semple I, Ho A, Park HW, Lee JH. Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue. Front Endocrinol (Lausanne). 2015;6:114. doi: 10.3389/fendo.2015.00114. eCollection 2015. Review. PubMed PMID: 26257706; PubMed Central PMCID: PMC4513567.

Kim M, Semple I, Kim B, Kiers A, Nam S, Park HW, Park H, Ro SH, Kim JS, Juhász G, Lee JH. Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis. Autophagy. 2015;11(8):1358-72. doi: 10.1080/15548627.2015.1063766. PubMed PMID: 26086452; PubMed Central PMCID: PMC4590642.

Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Mar 30;5:9502. doi: 10.1038/srep09502. PubMed PMID: 25819761; PubMed Central PMCID: PMC4377584.

Kim M, Lee JH. Identification of an AMPK phosphorylation site in Drosophila TSC2 (gigas) that regulate cell growth. Int J Mol Sci. 2015 Mar 27;16(4):7015-26. doi: 10.3390/ijms16047015. PubMed PMID: 25826530; PubMed Central PMCID: PMC4425001.

Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J. Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart. FASEB J. 2015 Feb;29(2):408-17. doi: 10.1096/fj.14-258814. Epub 2014 Nov 3. PubMed PMID: 25366347; PubMed Central PMCID: PMC4314228.

Park HW, Park H, Semple IA, Jang I, Ro SH, Kim M, Cazares VA, Stuenkel EL, Kim JJ, Kim JS, Lee JH. Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers. Nat Commun. 2014 Sep 5;5:4834. doi: 10.1038/ncomms5834. PubMed PMID: 25189398; PubMed Central PMCID: PMC4157315.

Ro SH, Semple IA, Park H, Park H, Park HW, Kim M, Kim JS, Lee JH. Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 2014 Sep;281(17):3816-27. doi: 10.1111/febs.12905. Epub 2014 Jul 28. PubMed PMID: 25040165; PubMed Central PMCID: PMC4156532.

Park HW, Park H, Ro SH, Jang I, Semple IA, Kim DN, Kim M, Nam M, Zhang D, Yin L, Lee JH. Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun. 2014 Jun 20;5:4233. doi: 10.1038/ncomms5233. PubMed PMID: 24947615; PubMed Central PMCID: PMC4074707.

Ro SH, Nam M, Jang I, Park HW, Park H, Semple IA, Kim M, Kim JS, Park H, Einat P, Damari G, Golikov M, Feinstein E, Lee JH. Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7849-54. doi: 10.1073/pnas.1401787111. Epub 2014 May 13. PubMed PMID: 24825887; PubMed Central PMCID: PMC4040599.

Park HW, Lee JH. Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies. Autophagy. 2014;10(12):2385-6. doi: 10.4161/15548627.2014.984268. Review. PubMed PMID: 25484079; PubMed Central PMCID: PMC4502701.

Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 1;20(1):133-44. doi: 10.1016/j.cmet.2014.05.001. Epub 2014 Jun 5. PubMed PMID: 24910242; PubMed Central PMCID: PMC4079758.

Kim M, Park HL, Park HW, Ro SH, Nam SG, Reed JM, Guan JL, Lee JH. Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging. Autophagy. 2013 Aug;9(8):1201-13. doi: 10.4161/auto.24811. Epub 2013 May 14. PubMed PMID: 23819996; PubMed Central PMCID: PMC3748192.

Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J Clin Invest. 2013 May;123(5):2231-43. doi: 10.1172/JCI64498. Epub 2013 Apr 8. PubMed PMID: 23563314; PubMed Central PMCID: PMC3635720.

Lee JH, Budanov AV, Karin M. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab. 2013 Dec 3;18(6):792-801. doi: 10.1016/j.cmet.2013.08.018. Epub 2013 Sep 19. Review. PubMed PMID: 24055102; PubMed Central PMCID: PMC3858445.

Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 5;16(3):311-21. doi: 10.1016/j.cmet.2012.08.004. PubMed PMID: 22958918; PubMed Central PMCID: PMC3687365.